Programme

SATURDAY, AUGUST 5

1-4pm Registration / Poster Set-Up

SUNDAY, AUGUST 6

8am-5pm Registration  
 
8:15am Welcome and Introduction Carol Black & Robert Lafyatis
SESSION 1
Advances in Gene Regulation
Chairs – David Abraham & Yannick Allanore
8:25 Introduction
8:30 LncRNAs and regulation of gene expression Howard Chang
9:30 Identification of unique cell populations in fibrotic mouse tissues using single cell sequencing Scott MacDonnell
10:00 Discussion
10:30 COFFEE BREAK
SESSION 2
Systems Biology and Computational Medicine
Chairs – Michael Whitfield & Shervin Assassi
10:55 Introduction  
11:00 Computational approaches for human disease -Gene prediction and ranking B.J. Aronow
11:30 Applying systems biology to systemic sclerosis Casey Greene
12:00pm Discussion
12:30 LUNCH
SESSION 3     
Genetics and Epigenetics
Chairs – Bashar Kahaleh & Maureen Mayes
1:55 Introduction  
2:00 Immunogenetics of systemic sclerosis: Defining heritability, functional variants and shared-autoimmunity pathways Javier Martin
2:30 Epigenetics of endothelium Eliza Tsou
3:00 Discussion
3:30 AFTERNOON TEA
SESSION 4
Interstitial Lung Disease
Chairs – Carol Feghali Bostwick & Mauricio Rojas
3:55 Introduction  
4:00 New insights into the pathogenesis and treatment of autoimmune interstitial lung diseases Kevin Gibson
4:30 Biomarkers and early phase clinical trials in IPF and ILD Toby Maher
5:00 Discussion
5:30 END of SESSION
5:45 WELCOME RECEPTION – University Club Rooftop Terrace

MONDAY, AUGUST 7

SESSION 5
Pulmonary Arterial Hypertension
Chairs – Harrison Farber & Virginia Steen
7:55am Introduction  
8:00 Inflammation in pulmonary arterial hypertension Mark Nicolls
8:30 Perivascular inflammation in pulmonary arterial hypertension Kurt Stenmark
9:00 Discussion
SESSION 6
Macrophages in Inflammation and Fibrosis
Chairs – Thomas Krieg & Masataka Kuwana
9:10 Introduction  
9:15 Macrophage development and homeostasis Frederic Geissmann
9:45 Macrophage polarization during wound healing Thomas Krieg
10:15 Discussion
10:30 COFFEE BREAK
SESSION 7
Adaptive Immunity and Fibrosis
Chairs – Armando Gabrielli & Patrizia Fuschiotti
10:55 Introduction
11:00 T cell regulation in autoimmune disease Dario Vignali
11:30 T cells and skin fibrosis Michael Rosenblum
12:00pm Fli1-deficient B cells contribute to the development of tissue fibrosis, vasculopathy, and immune abnormalities characteristic of systemic sclerosis Yoshihide Asano
12:30 Discussion
12:45  LUNCH
SESSION 8
Advances in Hematopoietic Stem Cell Transplant
Chairs – Paul Szabolcs & Carol Black
1:25 Introduction  
1:30 Stem cell transplant – Where are we? Alan Tyndall
2:00 Hematopoietic stem cell transplant – the U.S. experience Keith Sullivan
2:30 Advances in hematopoietic stem cell transplant David Scadden
3:00 Discussion
3:15 AFTERNOON TEA
SESSION 9
New Therapeutic Approaches and Translational Observations
Chairs – Robert Lafyatis & Francesco del Galdo
4:25 Introduction  
4:30 Bardoxolone in SSc-PAH Chris Wigley/Reata
4:45 The prostacyclin pathway in PAH and Raynaud’s:  Therapeutic opportunities for ralinepag John Adams/Arena
5:00 Resunab in SSc Barbara White/Corbus
5:15 CRISS informs past and future clinical trials Dinesh Khanna
5:45 Development of AVID200, an isoform-selective
TGF-beta inhibitor, for the treatment of
scleroderma
Maureen O’Connor/Formation
Biologics
6:00 Play ball!  Shuttle will leave from University Club at 6:15

7:05 PM Pittsburgh Pirates vs. Detroit Tigers, PNC Park

TUESDAY, AUGUST 8

SESSION 10
Mesenchymal Cell Populations in Skin and Adipogenesis
Chairs – John Varga & Richard Stratton
8:40am Introduction
8:45 Dermal fibroblast populations and Wnts in
fibrosis
Fiona Watt – Edith Busch Speaker
9:15 Adipocytes and macrophages in wound healing Valerie Horsley
9:45 Discussion
10:00 COFFEE BREAK
SESSION 11
Biomechanics of Fibroblasts
Chairs – Maria Trojanowska & Fiona Watt
10:40 Introduction
10:45 Cell tension/mechanics-mi-RNA21 Boris Hinz
11:15 Yap Taz in fibrosis Bob Varelas
11:45 Discussion
12:00pm LUNCH
SESSION 12
Selected Abstract Presentation
Chairs – Luc Mouthon & Marco Matucci Cerinic
1:25 Introduction  
1:30 PAN-PPAR AGONIST IVA337 IS EFFECTIVE IN THE PREVENTION OF EXPERIMENTAL LUNG FIBROSIS AND PULMONARY HYPERTENSION  Y. Allanore
1:45 CHANGES IN GENE EXPRESSION IN PATIENTS WITH SYSTEMIC SCLEROSIS TREATED WITH MYCOPHENOLATE MOFETIL (MMF) PLUS BELIMUMAB OR MMF PLUS PLACEBO  V. Martyanov
2:00 SIMULTANEOUS HIGH THROUGHPUT RNA-SEQ PROFILING OF SKIN, LUNG AND DERMAL FAT IN SSC  E. Roberson
2:15 EFFICACY OF M10, A CASPACE CLEAVAGE PRODUCT OF THE HGF RECEPTOR, IN BMP9-INDUCED FIBROSIS IN SCLERODERMA LUNG FIBROBLASTS  A. Noguchi
2:30 MYELOID FLI1 DEFICIENCY INDUCES VASCULOPATHY AND DERMAL FIBROSIS RECAPITULATING SYSTEMIC SCLEROSIS  T. Taniguchi
2:45 AUTOANTIGEN-REACTIVE B CELLS CONTRIBUTE TO PROGRESSION OF SYSTEMIC SCLEROSIS THROUGH B CELL AFFINITY MATURATION-DEPENDENT IL-6 AND IL-10 PRODUCTION  A. Yoshizaki
3 – 5pm ~ Poster Viewing ~ University Club Ballroom A 
 
6PM ~ BANQUET ~ Carnegie Museum Music Hall Foyer
Banquet Speaker:  Thomas Medsger, MD, Professor of Medicine Emeritus, University of Pittsburgh.

WEDNESDAY, AUGUST 9

SESSION 13
Scleroderma Mimics
Chairs – Peter Merkel & Murray Baron
7:55am Introduction
8:00 Immune responses and biomarkers of chronic GVHD Sophie Paczesny
8:30 Microangiopathy in HHT B.L. Roman
9:00 Discussion
SESSION 14
Oxidative Stress and Metabolic Signals
Chairs – Ana Mora & TBA
9:10 Introduction  
9:15 Oxidative stress in interstitial lung disease Victor Thannickal
9:45 Connection between NAD+ metabolism, CD38 and aging, and their potential implications for tissue remodeling, regeneration and fibrosis Eduardo Chini
10:15 Discussion
10:30 COFFEE BREAK  
SESSION 15
Reverse Translation
Chairs – Christopher Denton & Tracy Frech
10:55 Introduction
11:00 Riociguat in Systemic Sclerosis Janethe de Oliveira Pena/
Bayer
11:20 Blocking statins for SSc vascular disease Robyn Domsic
11:40 Therapeutic Interleukin-6 Receptor-a blockade reverses the phenotype of dermal fibroblasts in systemic sclerosis Thierry Sornasse
12:00pm Discussion
12:15 LUNCH
SESSION 16
Scleroderma Clinical Trials Consortium
Chairs – Murray Baron & Ariane Herrick
1:40 Introduction Murray Baron
1:45 Alternate ways to use the skin score to enhance the design and conduct of clinical trials in dcSSc Tom Medsger
2:00 Has anyone gone down this path before…and reached the end?
An industry perspective
Barbara White
3:00 Novel methodology to assess skin involvement Marie Hudson
3:30 Disease damage and activity Murray Baron
3:50 Patient reported outcomes:  Where do we stand? John Pauling
4:10 Panel discussion
END OF WORKSHOP